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Results for “High Risk Chronic Myelomonocytic Leukemia”

140 trials

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Showing 20 of 140 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT06098313
What this trial is testing

HCT With PTCy in Higher-risk MDS

Who this might be right for
Patients With MDS, Acute Myeloid Leukemia (AML) Evolving From MDS, and Chronic Myelomonocytic Leukemia (CMML)
Asan Medical Center 113
Testing effectiveness (Phase 2)WithdrawnNCT04217720
What this trial is testing

SNS-301 Monotherapy in High Risk MDS and CMML

Who this might be right for
Myelodysplastic SyndromesChronic Myelomonocytic Leukemia (CMML)
Sensei Biotherapeutics, Inc.
Early research (Phase 1)Looking for participantsNCT03896269
What this trial is testing

CPX-351 in Treating Patients With Relapsed or Refractory High Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Who this might be right for
Blasts 10-19 Percent of Bone Marrow Nucleated CellsBlasts More Than 5 Percent of Bone Marrow Nucleated CellsHigh Risk Chronic Myelomonocytic Leukemia+4 more
M.D. Anderson Cancer Center 38
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06900088
What this trial is testing

Selinexor Combined With Azacitidine Therapy in High-Risk Myeloid Neoplasms Patients

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic SyndromeChronic Myelomonocytic Leukemia
Institute of Hematology & Blood Diseases Hospital, China 20
Early research (Phase 1)Study completedNCT01629082
What this trial is testing

Clofarabine Followed By Lenalidomide for High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia

Who this might be right for
Myeldysplastic Syndrome (MDS)Chronic Myelomonocytic LeukemiaBone Marrow Diseases+2 more
National Heart, Lung, and Blood Institute (NHLBI) 4
Testing effectiveness (Phase 2)Study completedNCT02197676
What this trial is testing

A Phase II Trial of SGI-110 in Patients With IPSS High and Int 2 Myelodysplastic Syndrome, Acute Myeloid Leukemia With 20-30% Marrow Blasts or Chronic Myelomonocytic Leukemia Type 2 Not Responding to Azacitidine or Decitabine After at Least 6 Courses or Relapsing After a Response

Who this might be right for
MDS
Groupe Francophone des Myelodysplasies 56
Large-scale testing (Phase 3)Study completedNCT00005863
What this trial is testing

Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia

Who this might be right for
LeukemiaMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative Neoplasms
Medical Research Council
Testing effectiveness (Phase 2)Study completedNCT03047993
What this trial is testing

Glutaminase Inhibitor CB-839 and Azacitidine in Treating Patients With Advanced Myelodysplastic Syndrome

Who this might be right for
Acute Myeloid Leukemia With Multilineage DysplasiaBlasts 20-30 Percent of Bone Marrow Nucleated CellsBlasts 20-30 Percent of Peripheral Blood White Cells+4 more
M.D. Anderson Cancer Center 28
Early research (Phase 1)Ended earlyNCT00589316
What this trial is testing

Iodine I 131 Monoclonal Antibody BC8, Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation and Donor Bone Marrow Transplant in Treating Patients With Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or High-Risk Myelodysplastic Syndrome

Who this might be right for
Acute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAdult Acute Lymphoblastic Leukemia in RemissionAdult Acute Myeloid Leukemia in Remission+7 more
Fred Hutchinson Cancer Center
Testing effectiveness (Phase 2)Study completedNCT01177371
What this trial is testing

High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma

Who this might be right for
Accelerated Phase Chronic Myelogenous LeukemiaAdult Acute Lymphoblastic Leukemia in RemissionAdult Acute Megakaryoblastic Leukemia (M7)+70 more
Case Comprehensive Cancer Center 13
Large-scale testing (Phase 3)Study completedNCT00152139
What this trial is testing

Stem Cell Transplantation for Patients With Hematologic Malignancies

Who this might be right for
Acute Lymphoblastic LeukemiasAcute Myelocytic LeukemiaChronic Myeloid Leukemia+4 more
St. Jude Children's Research Hospital 33
Large-scale testing (Phase 3)Study completedNCT03268954
What this trial is testing

Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine as First-Line Treatment for Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML), or Low-Blast Acute Myelogenous Leukemia (AML)

Who this might be right for
Myelodysplastic SyndromeLeukemia, Myelomonocytic, ChronicLeukemia, Myeloid, Acute
Takeda 454
Early research (Phase 1)Study completedNCT00569283
What this trial is testing

Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant

Who this might be right for
Cancer
Asan Medical Center 18
Large-scale testing (Phase 3)Study completedNCT00005823
What this trial is testing

Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Who this might be right for
LeukemiaMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative Neoplasms
Leukemia Research Fund 2,000
Testing effectiveness (Phase 2)WithdrawnNCT05895201
What this trial is testing

High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Sitagliptin for the Prevention of GVHD

Who this might be right for
Bone Marrow Transplant ComplicationsAcute Myeloid LeukemiaAcute Lymphoblastic Leukemia, Adult+2 more
Indiana University
Testing effectiveness (Phase 2)Study completedNCT02756572
What this trial is testing

Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid Neoplasms

Who this might be right for
Blasts 10 Percent or More of Bone Marrow Nucleated CellsChronic Myelomonocytic Leukemia-2High Grade Malignant Neoplasm+6 more
University of Washington 30
Early research (Phase 1)Study completedNCT01169012
What this trial is testing

PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias

Who this might be right for
Myelodysplastic SyndromeAcute Myeloid LeukemiaAcute Lymphoblastic Leukemia+1 more
UNC Lineberger Comprehensive Cancer Center 13
Testing effectiveness (Phase 2)Study completedNCT02556931
What this trial is testing

Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies

Who this might be right for
Myelodysplastic SyndromeChronic Myelomonocytic LeukemiaSmall Lymphocytic Lymphoma+11 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 117
Testing effectiveness (Phase 2)WithdrawnNCT04264806
What this trial is testing

Cusatuzumab in Combination With Azacitidine Compared With Azacitidine Alone in Patients With Higher-risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML) and Who Are Not Candidates for Hematopoietic Stem Cell Transplantation (HSCT)

Who this might be right for
Myelodysplastic SyndromesLeukemia, Myelomonocytic, Chronic
Janssen Research & Development, LLC
Testing effectiveness (Phase 2)Looking for participantsNCT03383575
What this trial is testing

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

Who this might be right for
Acute Myeloid LeukemiaBlasts 20-30 Percent of Bone Marrow Nucleated CellsChronic Myelomonocytic Leukemia+4 more
M.D. Anderson Cancer Center 63
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