Testing effectiveness (Phase 2)Study completedNCT01071538What this trial is testingBuprenorphine for Late-Life Treatment Resistant DepressionWho this might be right forDepression University of Pittsburgh 15
Post-approval studies (Phase 4)Study completedNCT04504175What this trial is testingKetamine for Older Adults PilotWho this might be right forTreatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more Washington University School of Medicine 25
Early research (Phase 1)WithdrawnNCT03368560What this trial is testingA Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life DepressionWho this might be right forLate Life Depression London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Testing effectiveness (Phase 2)Study completedNCT04469959What this trial is testingDopaminergic Dysfunction in Late-Life DepressionWho this might be right forLate Life DepressionCognitive DeclineDepressive Disorder, Treatment-Resistant+2 more Vanderbilt University Medical Center 79
Not applicableUnknownNCT01760681What this trial is testingSham-Controlled Study of H-Coil Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Late-Life DepressionWho this might be right forDepression Shalvata Mental Health Center 60
Not applicableStudy completedNCT01860157What this trial is testingDeep rTMS for Treatment-Resistant Late-life DepressionWho this might be right forMajor Depressive Disorder Centre for Addiction and Mental Health 58
Not applicableEnded earlyNCT03564041What this trial is testingSSM vs HEP in Late-Life DepressionWho this might be right forLate-life DepressionTreatment-resistant Depression London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's 95
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07810738What this trial is testingThe BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.Who this might be right forLate Life Treatment Resistant DepressionDepression - Major Depressive DisorderTreatment Resistant Depression Washington University School of Medicine 300
Post-approval studies (Phase 4)Study completedNCT02960763What this trial is testingOptimizing Outcomes of Treatment-Resistant Depression in Older AdultsWho this might be right forTreatment Resistant DepressionMajor Depressive DisorderTreatment-Refractory Depression+2 more Washington University School of Medicine 742
Large-scale testing (Phase 3)Study completedNCT02556606What this trial is testingKetamine for Treatment Resistant Late-Life DepressionWho this might be right forTreatment Resistant Depressive Disorder VA Office of Research and Development 33
Testing effectiveness (Phase 2)Study completedNCT02181231What this trial is testingBuprenorphine Used With Treatment Resistant Depression in Older AdultsWho this might be right forMajor Depressive DisorderDepression Washington University School of Medicine 18
Not applicableStudy completedNCT05007028What this trial is testingNitrous Oxide for Late-Life Depression - PROTO-BRAINWho this might be right forLate-Life DepressionResistant Depression, Treatment University Hospital, Tours 60
Large-scale testing (Phase 3)Looking for participantsNCT07623135What this trial is testingLumateperone for Late-Life DepressionWho this might be right forTreatment Resistant Depression (TRD)Late Life Depression (LLD)Depression / Major Depressive Disorder Eric Lenze 100
Post-approval studies (Phase 4)Study completedNCT05531591What this trial is testingRCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)Who this might be right forDepressionDementiaMild Cognitive Impairment+5 more Centre for Addiction and Mental Health 87
Not applicableStudy completedNCT05204940What this trial is testingLongitudinal Observational Biomarker StudyWho this might be right forDepressionDementiaMild Cognitive Impairment Centre for Addiction and Mental Health 506
Not applicableLooking for participantsNCT06854367What this trial is testingAccelerated vs. Conventional Theta Burst Stimulation for Late-life DepressionWho this might be right forLate Life Depression (LLD)Depression - Major Depressive DisorderDepressive Disorder, Treatment-Resistant+1 more Centre for Addiction and Mental Health 280
Not applicableStudy completedNCT02998580What this trial is testingConventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life DepressionWho this might be right forMajor Depression Centre for Addiction and Mental Health 163
Post-approval studies (Phase 4)Study completedNCT00892047What this trial is testingIncomplete Response in Late Life Depression: Getting to Remission (IRL GREY)Who this might be right forDepression University of Pittsburgh 468
Not applicableUnknownNCT05119699What this trial is testingAccelerated TBS in Late Life DepressionWho this might be right forTreatment Resistant Depression Centre for Addiction and Mental Health 30