Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Single Gene Disorders”

391 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 391 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT07173933
What this trial is testing

Phase I/II Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of GC310 Injection in Patients With Wilson's Disease (WD)

Who this might be right for
Wilson Disease
GeneCradle Inc 15
Testing effectiveness (Phase 2)Looking for participantsNCT06323525
What this trial is testing

TCR Reserved and Power3 (SPPL3) Gene Knock-out Allogeneic CD19-targeting CAR-T Cell Therapy in r/r B Cell Lymphoma

Who this might be right for
Non-hodgkin Lymphoma
Chinese PLA General Hospital 30
Testing effectiveness (Phase 2)Looking for participantsNCT06922890
What this trial is testing

First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury

Who this might be right for
Spinal Cord InjuryChronic Spinal Cord Injury
Yonsei University 9
Testing effectiveness (Phase 2)Active Not RecruitingNCT06300476
What this trial is testing

Safety and Efficacy of a Single Subretinal Injection of JWK006 Gene Therapy in Subjects With Stargardt Disease(STGD1)

Who this might be right for
Stargardt Disease 1
West China Hospital 9
Testing effectiveness (Phase 2)UnknownNCT04753203
What this trial is testing

Alpelisib and Capecitabine in Patients With PIK3CA Mutant mCRC Patients

Who this might be right for
Metastatic Colorectal CancerPIK3CA Gene Mutation
Korean Cancer Study Group 65
Large-scale testing (Phase 3)Active Not RecruitingNCT06062810
What this trial is testing

Pharmacogenomics ANDA SNP Clinical Study - Raloxifene and Single Nucleotide Polymorphisms

Who this might be right for
Breast Cancer
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair 600
Large-scale testing (Phase 3)Study completedNCT02652767
What this trial is testing

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation

Who this might be right for
Optic, Atrophy, Hereditary, Leber
GenSight Biologics 39
Testing effectiveness (Phase 2)Looking for participantsNCT07007949
What this trial is testing

A New Treatment of Newly Diagnosed IDH1 Mutation Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid LeukemiaIDH1 Gene MutationIvosidenib
The First Affiliated Hospital of Soochow University 42
Testing effectiveness (Phase 2)Looking for participantsNCT06844214
What this trial is testing

Investigate the Safety, Tolerability, and Efficacy of SAR446268, an Adeno-associated Viral Vector-mediated Gene Therapy in Participants Aged 10 to 50 Years of Age With Non-congenital Myotonic Dystrophy Type 1

Who this might be right for
Myotonic Dystrophy
Sanofi 32
Not applicableEnded earlyNCT00675753
What this trial is testing

Three Interacting Single Nucleotide Polymorphisms (SNPs) and the Risk of Preterm Birth in Black Families

Who this might be right for
Premature Birth
University of Miami 258
Not applicableUnknownNCT00866151
What this trial is testing

A to Z Study Follow-up: Collection of DNA Data From Buccal Swabs

Who this might be right for
Weight ManagementDiet ConditionsDietary Recommendations+2 more
Interleukin Genetics, Inc. 150
Not applicableStudy completedNCT00898495
What this trial is testing

Genes in Predicting Outcome in Patients With Esophageal Cancer Treated With Cisplatin, Radiation Therapy, and Surgery

Who this might be right for
Esophageal Cancer
ECOG-ACRIN Cancer Research Group 118
Testing effectiveness (Phase 2)Study completedNCT01252641
What this trial is testing

Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Subjects

Who this might be right for
HIVHIV Infection
Sangamo Therapeutics 21
Large-scale testing (Phase 3)Study completedNCT02906202
What this trial is testing

A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Participants With Transfusion-Dependent β-Thalassemia, Who do Not Have a β0/β0 Genotype

Who this might be right for
Beta-Thalassemia
Genetix Biotherapeutics Inc. 24
Testing effectiveness (Phase 2)UnknownNCT04940637
What this trial is testing

UNITO-001- Study in HRR/PDL1 Positive MPM/NSCLC

Who this might be right for
Lung CancerMesothelioma
University of Turin, Italy 70
Testing effectiveness (Phase 2)UnknownNCT04882345
What this trial is testing

Almonertinib Treats Advanced NSCLC Patients With EGFR Mutations Who Are Safety Intolerant After Osimertinib Treatment

Who this might be right for
Lung CancerEGFR Gene Mutation
Shanghai Chest Hospital 40
Testing effectiveness (Phase 2)Looking for participantsNCT06421298
What this trial is testing

A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

Who this might be right for
Lung Cancer
Jinghui Wang 30
Large-scale testing (Phase 3)Not Yet RecruitingNCT05970900
What this trial is testing

Preoperative Imatinib Mesylate Combined With Rectal-sparing Surgery in Patients With c-KIT Gene-mutant Rectal GIST

Who this might be right for
Gastrointestinal Stromal Tumor of Rectum
Fujian Medical University Union Hospital 23
Testing effectiveness (Phase 2)UnknownNCT01278277
What this trial is testing

Saffron Supplementation in Stargardt's Disease

Who this might be right for
Retinal DegenerationGenetic DiseaseSingle-Gene Defects+1 more
Catholic University of the Sacred Heart 30
Early research (Phase 1)Looking for participantsNCT06447662
What this trial is testing

Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

Who this might be right for
Carcinoma, Pancreatic DuctalColorectal NeoplasmsCarcinoma, Non-Small-Cell Lung
Pfizer 330
Load More Results