Not applicableLooking for participantsNCT06115148What this trial is testingBreath Analysis & MalnutritionWho this might be right forMalnutrition Pennington Biomedical Research Center 12
Not applicableStudy completedNCT01151475What this trial is testingCerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy (HE)Who this might be right forLiver CirrhosisHepatic Encephalopathy University of Aarhus 10
Not applicableStudy completedNCT00472732What this trial is testingNeurologic Injuries in Adults With Urea Cycle DisordersWho this might be right forBrain Diseases, Metabolic, InbornUrea Cycle DisorderOrnithine Transcarbamylase Deficiency Andrea Gropman 46
Not applicableStudy completedNCT04269122What this trial is testingAssess Plasma Ammonia Time-Normalized Area Under the Curve and Rate of Ureagenesis in Healthy Adult SubjectsWho this might be right forOrnithine Transcarbamylase Deficiency Ultragenyx Pharmaceutical Inc 120
Not applicableStudy completedNCT03797131What this trial is testingClinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle DisordersWho this might be right forUrea Cycle Disorders Kaleido Biosciences 4
Testing effectiveness (Phase 2)Ended earlyNCT03933410What this trial is testingUNLOCKED: A Phase 2, Open-label Trial With KB195 in Subjects With a Urea Cycle DisorderWho this might be right forUrea Cycle Disorder Kaleido Biosciences 13
Not applicableUnknownNCT04585672What this trial is testingAmmonia Metabolism Assessed by Ammonia InfusionWho this might be right forAmmonia; Metabolic DisorderLiver Failure, Chronic Aarhus University Hospital 20
Not applicableEnrolling By InvitationNCT06987604What this trial is testingContinuous Renal Replacement Therapy Intensity in HyperammonemiaWho this might be right forAcute Liver FailureAcute on Chronic Liver Failure (ACLF)Acute Kidney Injury+1 more Hospital de Clinicas de Porto Alegre 152
Not applicableStudy completedNCT00836420What this trial is testingCerebral Microdialysis in Patients With Fulminant Hepatic FailureWho this might be right forFulminant Hepatic Failure Rigshospitalet, Denmark 50
Testing effectiveness (Phase 2)Ended earlyNCT06987968What this trial is testingSee if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic EncephalopathyWho this might be right forHepatic EncephalopathyAcute on Chronic Liver Failure (ACLF)Decompensated Cirrhosis Genfit 3
Not applicableStudy completedNCT00424957What this trial is testingBrain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous SystemWho this might be right forCirrhosisHepatic Encephalopathy University of Aarhus 18
Large-scale testing (Phase 3)UnknownNCT03021876What this trial is testingL-carnitine Corrects Ammonia Metabolism in Hepatectomized PatientsWho this might be right forAmmonia Metabolism Kochi University 80
Testing effectiveness (Phase 2)Looking for participantsNCT06255782What this trial is testingAn Open-label Study to Investigate ECUR-506 in Male Babies Less Than 9 Months of Age With Neonatal Onset OTC DeficiencyWho this might be right forOrnithine Transcarbamylase DeficiencyOrnithine Transcarbamylase Deficiency DiseaseOrnithine Carbamoyltransferase Deficiency (Disorder)+1 more iECURE, Inc. 20
Testing effectiveness (Phase 2)UnknownNCT02334163What this trial is testingThe Effects of Nitazoxanide in Hepatic EncephalopathyWho this might be right forHepatic Encephalopathy Ain Shams University 36
Large-scale testing (Phase 3)WithdrawnNCT04128462What this trial is testingMNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain FunctionWho this might be right forHepatic Encephalopathy Mallinckrodt
Not applicableLooking for participantsNCT06805695What this trial is testingLong-term Follow-up (LTFU) Study of Participants in Any iECURE Protocol Using an Investigational Product (IP)Who this might be right forOrnithine Transcarbamylase DeficiencyOrnithine Transcarbamylase Deficiency DiseaseUrea Cycle Disorders, Inborn iECURE, Inc. 13
Post-approval studies (Phase 4)Study completedNCT03335488What this trial is testingStudy of Glycerol Phenylbutyrate & Sodium Phenylbutyrate in Phenylbutyrate Naïve Patients With Urea Cycle Disorders (UCDs)Who this might be right forUrea Cycle Disorder Amgen 16
Not applicableStudy completedNCT00931060What this trial is testingEffects of Branched-Chain Amino Acids on Muscle Ammonia Metabolism in Patients With Cirrhosis and Healthy SubjectsWho this might be right forLiver DiseasesHepatic EncephalopathyHepatic Insufficiency University of Aarhus 24
Not applicableEnded earlyNCT01948427What this trial is testingObservational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs)Who this might be right forUrea Cycle Disorder Amgen 203
Not applicableEnrolling By InvitationNCT06953505What this trial is testingAt Home Ammonia Monitoring of Inborn Errors of Ammonia MetabolismWho this might be right forUrea Cycle DisordersOrganic AcidemiasFatty Acid Oxidation Disorder+1 more Sequitur Health Corp. 30